BIOENERGETICS-BASED MODELING OF PLASMODIUM FALCIPARUM METABOLISM REVEALS ITS ESSENTIAL GENES, NUTRITIONAL REQUIREMENTS, AND THERMODYNAMIC BOTTLENECKS.

Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks.

Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites.The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex.Computational stickers logos dallas cowboys methods can handle this complexity and allow integrative analyses of cell metabolism.In this s

read more

Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy

Drug resistance is one of the major simply southern cat shirt causes of cancer-related deaths.Here, the authors using single cell RNA-seq of oral squamous cell carcinoma patient samples pre- and post-cisplatin treatment show that phenotypically homogenous cell populations display cell state plasticity, with poised chromatin marks at mesenchymal gen

read more

Strategic reactions to information content of dividend change: applying BCG growth share matrix when signalling hypothesis identified

here The signaling hypothesis has been vastly under investigation for many years.There are two attitudes towards this phenomenon; some believe that firms increase (decrease) their dividend to signal about the future increases in earnings due to asymmetric information that managers have.Adversely, others believe that firms usually increase their div

read more


Type 1 diabetes peer support groups: Bridging the gap between healthcare professionals and people with type 1 diabetes

Type 1 diabetes (T1D) is emerging as a hp pavilion 15-eg1053cl major healthcare challenge impacting a significant percentage of the population.Management of T1D remains a concern in India with the diversity in socio-economic backgrounds, poor literacy levels, and inadequate resources and facilities which impact timely diagnosis, treatment, and mana

read more